I started by using Adobe InDesign, but I'm not really that familiar with it's workings and was having to turn to the help at every stage. So I switched to Serif PagepPlus 9 which I have used fairly extensively.
I created a master on an A4 sheet which gives me 4 small areas and a larger one, so I can show 4 stages plus the final.
I printed my sample on fine art paper and was pleased with the result, it has given me something to work from. It obviously needs a bit of fine tuning but at least I have the basics worked out.
As I own both a comb binder and a laminator I should be able to create quite a substantial end result.